My daughter Masyitha has just been diagnosed as having Seronegative Arthritis.
I believe your relative actually has what is referred to as "Sero Negative Arthritis." This is a form of arthritis that is characterized by inflammation (hot, swollen, tender, painful, stiff) of joints, but is not associated with the classic blood test for rheumatoid arthritis called rheumatoid factor. We refer to these patients as being rheumatoid factor negative in their serum, or seronegative.
The term is nonspecific, and it is possible for a patient's condition to evolve at a later time into a more classical, identifiable disease.
Ask the Experts: Sero Negative Arthritis on MedicineNet.com
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